Neuroprotection is the term used to describe the strategies that are employed to prevent neuronal death and slow down the progression of neurodegenerative diseases. One such strategy that has gained significant attention in recent years is the use of glutathione (GSH) for neuroprotection. GSH is a tripeptide made up of three amino acids - glutamine, cysteine, and glycine. It plays a vital role in maintaining cellular redox balance, detoxification, immune function, and cellular signaling. As one of the most important antioxidants in the brain, GSH is essential for the protection of neurons against oxidative stress, inflammation, and apoptosis. Oxidative stress is a condition in which high levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced that can damage cellular macromolecules such as proteins, lipids, and DNA. This can lead to neuronal dysfunction and death, which are hallmarks of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Research has shown that GSH levels are significantly depleted in the brains of patients with neurodegenerative diseases. This decrease in GSH levels is thought to contribute to the development and progression of these diseases. Therefore, by increasing GSH levels in the brain, it may be possible to prevent or slow down the progression of neurodegenerative diseases. One of the most promising strategies for increasing GSH levels in the brain is the use of GSH precursors such as N-acetylcysteine (NAC) and alpha-lipoic acid (ALA). These precursors are converted to GSH in the body and have been shown to increase GSH levels in the brain. Additionally, other GSH-boosting agents such as melatonin, curcumin, and resveratrol are also being studied for their potential neuroprotective effects. In conclusion, GSH is a crucial molecule for maintaining neuronal health and function. By increasing GSH levels in the brain, it may be possible to protect neurons against oxidative stress, inflammation, and apoptosis, thereby preventing or slowing down the progression of neurodegenerative diseases. However, more research is needed to fully understand the mechanisms underlying GSH-mediated neuroprotection and to develop effective GSH-boosting therapies for the treatment of neurodegenerative diseases.