Glutathione As A Biomarker For Health: How It Works Glutathione, also known as GSH, is a tripeptide molecule composed of three amino acids - cysteine, glycine, and glutamic acid. It is one of the most important endogenous antioxidants that is present in the human body and plays a critical role in maintaining cellular homeostasis. As a biomarker for health, glutathione is a valuable indicator of a person's overall wellbeing. It serves as a critical factor in preventing oxidative stress, promoting detoxification, and regulating immune responses. The levels of glutathione can be determined by analyzing different biomaterials like plasma, erythrocytes, and urine, which usually aids in understanding the level of oxidative stress present in an individual. The working mechanisms of glutathione are quite simple and straightforward. It works by binding to free radicals and toxins that can cause cell damage during various biological processes, thereby reducing their harm to the body. It also helps in the recycling of other antioxidants like vitamin E and C, which further helps to maintain a healthy balance of oxidants and antioxidants. The application of advanced technology in the production and measurement of glutathione levels has revolutionized the field of biomarker analysis. These technologies, such as enzyme-linked immunosorbent assay (ELISA) and high-performance liquid chromatography (HPLC), have enabled efficient and accurate analysis of glutathione. For instance, an ELISA-based assay can measure the GSH concentration in plasma with a sensitivity of 0.5 μM, which makes it a highly sensitive tool for evaluating the levels of GSH in biological fluids. Similarly, HPLC can help in determining the levels of glutathione in urine, erythrocytes, and liver. Glutathione also finds its applications in several practical scenarios. For example, it has been widely used as a biomarker for individuals exposed to toxic substances like benzene, arsenic, and pesticides. It is also used for analyzing chronic diseases like cancer, diabetes, and neurodegenerative disorders, where oxidative stress plays a critical role in the pathogenesis. In conclusion, Glutathione as a Biomarker for Health works by helping the body maintain cellular homeostasis and keeping the harmful effects of oxidative stress at bay. Advanced technologies like ELISA and HPLC have contributed significantly to the accurate and efficient evaluation of glutathione levels in biological fluids. The importance of this biomarker cannot be understated, considering its potential applications in various fields of research. If you want to know more about glutathione as a biomarker, contact us for further information. We are one of the leading suppliers of analytical solutions to researchers worldwide.